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The GEF-5 strategy for chemicals sets to consolidate the persistent organic pollutants (POPs) and ozone layer depletion focal areas, as well as to broaden the scope of GEF's engagement with the sound management of chemicals and to initiate work on mercury.

The goal of the GEF's chemicals focal area is to promote the sound management of chemicals throughout their life-cycle in ways that lead to the minimization of significant adverse effects on human health and the global environment.